US2005054563A120050310US2005054563A120050310US2005054563US39909303National20030414US3990930320030414USUS20030399093US2412220020001016USUS20000241222PUS013214220011012USWO2001US3214260241222PCT/US01/32142US200505456320050310A1A61K 3800LA20130101EPBHA61P 1900LI20200320EPBHA61P 1902LI20200320EPBHA61P 2900LI20200325EPBHC07K 14475FI20130101EPBHC07K 1447LI20130101EPBHA61K 38/00 20060101AFI20051220RMJP 20060101AFI20051220RMJPA61K3800A61P 19/02 20060101ALI20051220RMJP 20060101ALI20051220RMJPA61P1902A61P 29/00 20060101ALI20051220RMJP 20060101ALI20051220RMJPA61P2900C07K 14/47 20060101A I20051008RMEP 20060101ALI20051008RMEPC07K1447C07K 14/475 20060101A I20051008RMEP 20060101ALI20051008RMEPC07K14475C12N 15/12 20060101A I20060521RMWO 20060101ALI20060521RMWOC12N1512Methods of treatment using wisp polypeptidesUS5408040A19950418US6387657B120020514US5444047A19950822US2003180891A120030925US2003199440A120031023US6812339B120041102US2002192209A120021219DESNOYER LUCUSFILVAROFF ELLEN HUSPENNICA DIANEUSDESNOYER LUCFILVAROFF ELLEN H.PENNICA DIANEDESNOYER LUCFILVAROFF ELLEN H.PENNICA DIANEA transgenic bacterial host cell that can be used as a screen for novel antibiotics and herbicides is provided. The genome of the transgenic bacterial host cell comprises disruptions in a first endogenous gene in the MEP pathway) and a transgene that functionally replaces the disrupted first gene. In other embodiments, the genome comprises a disruption in a first endogenous gene in the MEP pathway and a second endogenous gene which is located downstream of the first gene in the MEP pathway. A transgene that functionally replaces the disrupted downstream gene is cloned into the host cell. A mini operon containing the essential genes for the MVA pathway may also be cloned into the host cell. The transgenic host cell may be used in a method for screening compounds for antibiotic and herbicidal properties. The agents determined by the screening method may be used to kill bacteria or plants.