US0005866419A19990202US5866419A19990202US5866419US71311596National19960916US7131159619960916USUS19960713115C12M 2712FI20130101EPBHC12M 2308LI20130101EPBHY10S 21508LA20130518EPBHC12M 3/04 20060101A I20051008RMEP 20060101ALI20051008RMEPC12M304Roller bottleUS99612A18700208US1241176A19170925US3702806A19721114US3941661A19760302US4074778A19780221US4238568A19801209US4283495A19810811US4317886A19820302US4330216A19820518US4337104A19820629US4448879A19840515US4517293A19850514US4717668A19880105US4749654A19880607US4761936A19880809US4810652A19890307US4824787A19890425US4829004A19890509US4912048A19900327US4912058A19900327US4962033A19901009US4966853A19901030US5010013A19910423US5016688A19910521US5084393A19920128US5151366A19920929US5152592A19921006US5168058A19921201US5272084A19931221US5330908A19940719US5426037A19950620US5645190A19970708FR912772A19460820DE2536097A119770303Voelcker, H.B., Let s Talk About Size, Tooling and Production, Sep. 1995, pp. 17 20.M. Gardner, The Unexpected Hanging , Simon and Schuster, New York, 1969, pp. 212 225.H. Rademacher et al., The Enjoyment of Mathematics , Princeton University Press, Princeton, 1957, pp. 163 177.J. Casey et al., Reuleaux Design Tutorial , Feb. 14, 1996, on Internet at http://commando.me.berkeley.edu/ willchui/tutorial.html.Anon., Magic Geometric Constants , Dec. 30, 1995, on Internet at http://www.mathsoft.com/asolve/constant/magic/magic/html.MEDER MARTIN GUSMEDER; MARTIN G.MEDER; MARTIN G.MEDER; MARTIN G.The invention is a roller bottle having a cross-section that is substantially a non-circular closed curve of constant width, wherein said curve is preferably a Reuleaux triangle or a Reuleaux triangle with rounded corners and the use of the roller bottle for cell culture. This provides several benefits: 1) a larger surface area per unit volume than a circular cross-section, promoting growth of anchorage dependant cells while maintaining an easily harvested and cleaned smooth wall. 2) a translational motion in addition to the usual circular motion, which is expected to enhance gas exchange, especially at the cap, which normally sits on an axis and has low angular velocity. 3) greater agitation of the growth medium inside the bottle, without the need for difficult to manufacture inserts or internal baffles.